Manganese carbonyl-encapsulated Fe-MOFs as a H2O2-responsive CO gas nanogenerator for synergistic gas/chemodynamic therapy

Abstract

The combination of chemodynamic therapy (CDT) and gas therapy holds significant promise for tumor treatment. In this study, we successfully synthesized an intelligent H₂O₂-responsive Fe-MOF nanotherapeutic agent, integrated with glucose oxidase (GOx) and manganese carbonyl (MnCO), to achieve synergistic cancer gas/CDT. Upon endocytosis by tumor cells, the nanotherapeutic agent catalyzes the conversion of endogenous glucose into gluconic acid and H₂O₂, which facilitates the release of CO gas and disrupts the energy supply. Subsequently, a Fenton reaction occurs between Fe-MOFs and intracellular H₂O₂, generating highly toxic hydroxyl radicals (˙OH) for CDT. Therefore, the engineered nanotherapeutic agent demonstrates a synergistic efficacy through CO gas therapy, reactive oxygen species (ROS)-mediated CDT, and energy starvation, effectively suppressing tumor growth.