Issue 23, 2025

Polyol-assisted chitosan-coated MnFe2O4 nanoparticles: assessing magneto-hyperthermia efficacy and toxicological effects on Garra mcclellandi fish

Abstract

Mn-ferrite and chitosan (CTS)-coated Mn-ferrite nanomaterials were synthesized using the polyol method with ethylene glycol as a reducing and stabilizing agent. This approach provided precise control over particle size, yielding Mn-ferrite (∼10 nm) and CTS-coated Mn-ferrite (∼15 nm) nanoparticles. SEM analysis confirmed a uniform spherical morphology for Mn-ferrite, while CTS coating introduced a rough surface texture. SQUID studies revealed a saturation magnetization (Ms) of 42.18 emu g−1 at 300 K, with negligible reduction upon CTS coating. The hyperthermia efficiency was assessed by varying the AC magnetic field (300–400 A) and material concentration (1–5 mg mL−1). At 335.2 Oe and 1 mg mL−1, Mn-ferrite and CTS-coated Mn-ferrite exhibited specific loss power (SLP) values of 223.47 W g−1 and 209.05 W g−1, respectively. Cytotoxicity studies on Garra mcclellandi fish demonstrated that both materials were non-toxic, with no structural damage observed in vital organs at 25 and 50 mg L−1 dosages. The study successfully demonstrated the synthesis of biocompatible, ferromagnetic nanomaterials with superior heating capabilities. These results suggest that CTS-coated Mn-ferrite nanoparticles are promising candidates for magneto-hyperthermia treatment (MTH), offering a balance of magnetic efficiency and biocompatibility.

Graphical abstract: Polyol-assisted chitosan-coated MnFe2O4 nanoparticles: assessing magneto-hyperthermia efficacy and toxicological effects on Garra mcclellandi fish

Supplementary files

Article information

Article type
Paper
Submitted
09 Feb 2025
Accepted
23 Mar 2025
First published
22 May 2025

New J. Chem., 2025,49, 9734-9746

Polyol-assisted chitosan-coated MnFe2O4 nanoparticles: assessing magneto-hyperthermia efficacy and toxicological effects on Garra mcclellandi fish

A. B. Pandhare, S. V. Mulik, O. S. Nille, D. B. Malavekar, J. H. Kim, N. B. Birajdar, S. B. Somvanshi, S. S. Phalake, Vishwajeet. M. Khot, R. P. Patil and S. D. Delekar, New J. Chem., 2025, 49, 9734 DOI: 10.1039/D5NJ00538H

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