α-Ni(OH)2@DEHP nanoparticles for fabrication of non-enzymatic electrochemical glucose sensor

Abstract

In this study, α-Ni(OH)2@DEHP nanoparticles were prepared by particle extraction through the liquid-liquid interface (PELLI) method using di(2-ethylhexyl) phosphoric acid (HDEHP)as a capping and phase transfer agent. The prepared α-Ni(OH)2@DEHP nanoparticles were characterized by FTIR, XRD,XPS, FE-SEM, and EDAX analysis. α-Ni(OH)2@DEHP/CPE was then fabricated for non-enzymatic electrochemical sensing of glucose. The developed electrochemical sensor shows high sensitivity and selectivity towards glucose in the presence of potential intrusive biomolecules, such as uric acid, ascorbic acid, and dopamine. The limit of detection (LOD), the limit of quantification (LOQ), and the linear calibration range of glucose were found to be 0.0009 mM, 0.033 mM, and 50 µM - 6.0 mM, respectively, and the sensitivity is 283.366 µA cm-2 mM-1. Finally, the prepared sensor was successfully used to determine low glucose concentration in blood samples with high recovery rates.