Selective cell labeling is the key to understanding of life processes. Here, we report an enzyme-mediated click reaction for selective cell labeling. Overexpressed alkaline phosphatase on target cells converts phosphorylated ascorbic acid, reducing Cu(II) to Cu(I), thereby catalyzing the click reaction for precise labeling.
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L. Li, Z. Li, Y. Qian, G. Tong, B. Dai and G. Liu, New J. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5NJ01360G
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