From the journal:

Natural Product Reports

Recent highlights of the total synthesis of cyclic peptide natural products

Takayuki Doi, ORCID logo *a   Masaya Kumashiroa  and  Kosuke Ohsawa ORCID logo ab  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan
E-mail: doi_taka@mail.pharm.tohoku.ac.jp

b Faculty of Pharmacy, Juntendo University, 6-8-1 Hinode, Urayasu, Japan

Abstract

Covering: 2020 to 2022

This review described the total synthesis of naturally occurring cyclic peptides with unique structures covering 2020 to 2022, i.e., darobactin A, pyritide A2, decatransin, mannopeptimycin β, α- and β-amanitins, orfamide A, and MA026, paying particular attention to the construction of their unique structures via macrocyclization.

Graphical abstract: Recent highlights of the total synthesis of cyclic peptide natural products

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Article information

DOI
https://doi.org/10.1039/D4NP00056K
Article type
Review Article
Submitted
15 Oct 2024
First published
14 May 2025
This article is Open Access
Creative Commons BY license

Nat. Prod. Rep., 2025, Advance Article

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Recent highlights of the total synthesis of cyclic peptide natural products

T. Doi, M. Kumashiro and K. Ohsawa, Nat. Prod. Rep., 2025, Advance Article , DOI: 10.1039/D4NP00056K

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