Recent progress of [5 + 2] cycloaddition reactions in natural product synthesis

Abstract

Covering: 2013 to 2024

Cycloaddition reactions, which efficiently construct polycyclic ring systems and stereocenters, are powerful tools in the total synthesis of natural products. Given the significant progress and numerous elegant applications of [5 + 2] cycloaddition reactions over the past decade, this review systematically summarizes the advances in three major types of [5 + 2] cycloaddition reactions in natural product synthesis from 2013 to 2024. The advantages of [5 + 2] cycloadditions in constructing complex natural product frameworks are illustrated through comparisons with alternative strategies for the same targets. Additionally, trends and future prospects for [5 + 2] cycloadditions are discussed, offering valuable insights for further research and broader applications.