Aminocarbonylation using CO surrogates

Abstract

Aminocarbonylation reactions play a critical role in the synthesis of amides. Traditional aminocarbonylation processes often rely on carbon monoxide (CO) gas, a highly toxic and challenging reagent to handle. Recent advancements in CO surrogates address these challenges. This review looks at the various CO substitutes used in aminocarbonylation reactions. These include metal carbonyls, acids, formates, chloroform, and others that release CO. Use of CO surrogates not only improves safety but also broadens the substrate scope and operational simplicity of the aminocarbonylation reactions. This review provides a summary of recent progress made in aminocarbonylation reactions using different CO surrogates. We discuss key methodologies, catalytic systems, and mechanistic insights, highlighting the efficiency and versatility of CO surrogates in amide bond formation.