Visible-light-mediated radical difunctionalization of alkenes with aromatic aldehydes

Abstract

We have developed a visible-light-mediated three-component tandem reaction of aromatic aldehydes with acrylates using a Hantzsch ester as the hydrogen atom transfer reagent, generating diethyl pentanedioate products in a one-pot synthesis. The reaction facilitates direct formation of acyl groups from the corresponding aldehydes, which are subsequently coupled successively to two molecules of acrylate in a Giese addition.