The present study reveals a practical one-pot base-promoted regio-divergent cyclization of hydrazines with alkynyl silane under mild conditions, facilitating the synthesis of diverse silicone-substituted pyrazoles and functionalized pyrazoles in great yields with exceptional selectivity. This protocol is expected to afford a streamlined one-pot approach for the synthesis of multiple compounds in water.
M. Pang, A. Ramazani, Z. Zhang and G. Zhang, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5OB00030K
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