Divergent synthetic studies towards bisabosqual A and fargenone B via an intramolecular SN2 reaction

Abstract

A divergent approach has been developed towards the synthetic studies of bisabosqual A and fargenone B for the first time. The key oxygenated five- or seven-membered ring in [6–5–6] and [6–7–6] tricyclic cores of these two natural products could be constructed through a regioselective intramolecular S_N2 reaction from the common advanced intermediate 11.