A scalable, diastereoselective protocol for synthesizing scarce 2-substituted cyclopropanols is presented. Our previous protocol of vinyl boron pinacolates cyclopropanation is adapted for flow conditions. The fundamental understanding of the stability of cyclopropanols under the formation conditions and the impact of the nature of substituents on it is demonstrated.
S. I. Shuvakin, O. M. Serhieiev, M. O. Dashko, V. V. Pendiukh, S. P. Ivonin, A. B. Rozhenko, O. Ye. Pashenko, S. V. Ryabukhin, D. M. Volochnyuk and S. V. Shishkina, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5OB00691K
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