One-pot synthesis of sulfonyl 3,6-diarylpyridazines via tandem condensation of α-sulfonyl ketones with methyl ketones

Meng-Yang Chang; Chen-Yo Ou

doi:10.1039/D5OB01051A

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One-pot synthesis of sulfonyl 3,6-diarylpyridazines via tandem condensation of α-sulfonyl ketones with methyl ketones†

Meng-Yang Chang

*^abc and Chen-Yo Ou^a

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* Corresponding authors

^a Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan
E-mail: mychang@kmu.edu.tw

^b Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan

^c NPUST College of Professional Studies, National Pingtung University of Science and Technology, Pingtung 912, Taiwan

Abstract

The tandem condensation of α-sulfonyl ketones and methyl ketones produces diverse sulfonyl pyridazines in yields of 70%–84% by one-pot Riley oxidation, Knoevenagel condensation, and sequential dehydrative imine formation.

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DOI: https://doi.org/10.1039/D5OB01051A
Article type: Paper
Submitted: 27 Jun 2025
Accepted: 15 Jul 2025
First published: 16 Jul 2025

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Org. Biomol. Chem., 2025, Advance Article

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One-pot synthesis of sulfonyl 3,6-diarylpyridazines via tandem condensation of α-sulfonyl ketones with methyl ketones

M. Chang and C. Ou, Org. Biomol. Chem., 2025, Advance Article , DOI: 10.1039/D5OB01051A

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Organic & Biomolecular Chemistry

One-pot synthesis of sulfonyl 3,6-diarylpyridazines via tandem condensation of α-sulfonyl ketones with methyl ketones†

Abstract

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One-pot synthesis of sulfonyl 3,6-diarylpyridazines via tandem condensation of α-sulfonyl ketones with methyl ketones

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