Magic effect of diphenylprolinol silyl ether for the enantioselective allenation of 2-alkynals

Abstract

Diphenylprolinol silyl ethers have been successfully identified as efficient chiral amines in the enantioselective allenation reaction of terminal alkynes and 2-alkynals. This reaction provides a diverse set of chiral allenynes with excellent enantioselectivity and decent yields. Furthermore, the current protocol is also compatible for the late-stage modification of some complex bioactive molecules, highlighting its potential in drug discovery.