Catalytic asymmetric synthesis and synthetic application of heteroatom-substituted axially chiral allenes

Abstract

The axially chiral allene framework has garnered significant attention from the synthetic community owing to its wide occurrence and application in natural products, organic synthesis, pharmaceuticals, and materials science. Among the structurally diverse chiral allene compounds, heteroatom-substituted axially chiral allenes represent a large and versatile subclass. Although the utility of heteroatom-substituted chiral allenes has been extensively explored, the asymmetric synthesis of these valuable chiral frameworks presents a long-standing challenge. Benefitting from the development of asymmetric catalysis, many efficient synthetic methods in enantioselective catalysis and a variety of competent reaction partners have recently emerged. This review primarily summarizes the contributions made to date to the catalytic asymmetric synthesis and synthetic applications of heteroatom-substituted axially chiral allenes.