Ni(II)-Catalyzed Enantioselective α-Hydrazination of α-Fluoroesters: Access to Chiral Quaternary α-Fluorinated α-Amino Acid Derivatives

Abstract

A highly catalytic asymmetric α-amination of α-azaaryl-α-fluoro esters with azodicarboxylates as the electrophilic aminating agents was reported. With C1-symmetric imidazolidine-pyrroloimidazolone pyridine as the tridentate ligand and Ni(BF4)2‧6H2O as the Lewis acid, diverse chiral α-hydrazino-α-fluorinated ester derivatives were obtained in high yields (up to 97% yield) and excellent enantioselectivities (up to 98% ee).