Transition-metal-free synthesis of C3,5-difunctionalized oxindole derivatives

Abstract

Herein, a new one-pot transition-metal-free catalytic method for the synthesis of C3, 5-disubstituted oxindoles has been developed. The protocol features good functional group tolerance, mild reaction conditions and atom economy. In addition, this protocol provides a platform for the synthesis of novel and complex oxindole derivatives with the potential for biological activity.

Supplementary files

Article information

Article type
Research Article
Submitted
27 Dec 2024
Accepted
20 Feb 2025
First published
22 Feb 2025

Org. Chem. Front., 2025, Accepted Manuscript

Transition-metal-free synthesis of C3,5-difunctionalized oxindole derivatives

Y. Liu, P. Zhang, L. Feng, Z. Zhang and T. Liang, Org. Chem. Front., 2025, Accepted Manuscript , DOI: 10.1039/D4QO02428A

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