Transition-metal-free synthesis of C3,5-difunctionalized oxindole derivatives
Abstract
Herein, a new one-pot transition-metal-free catalytic method for the synthesis of C3, 5-disubstituted oxindoles has been developed. The protocol features good functional group tolerance, mild reaction conditions and atom economy. In addition, this protocol provides a platform for the synthesis of novel and complex oxindole derivatives with the potential for biological activity.