Oxidative copper-catalyzed synthesis of β-amino ketones from allyl alcohols and anilines

Abstract

A copper-catalyzed method has been developed for synthesizing β-amino ketones using allyl alcohols and substituted anilines in 2-methyl-THF at 60 °C. This reaction employs hydrogen peroxide (H₂O₂) as the oxidant and cesium carbonate as the base. Cost-effectiveness, and a very good yield (65-82%) make this process a helpful alternative to the Pd-catalyzed coupling reaction of allylic alcohols with substituted anilines or substituted N-alkyl anilines.