One pot synthesis of SeTe–ZnO nanoparticles for antibacterial and wound healing applications

Abstract

Bacterial infections, particularly those involving biofilms, pose significant treatment challenges due to their resistance to traditional antibiotics. Herein, this research explores the integration of selenium–tellurium nanoparticles (SeTe NP) and zinc oxide (ZnO) NP to create hybrid NP with dual photodynamic and photothermal properties. The synthesized SeTe–ZnO NP demonstrated significant efficacy against both Gram-positive Staphylococcus aureus (S. aureus), Staphylococcus epidermidis (S. epidermidis) and Gram-negative Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) bacteria, effectively disrupting biofilm formation and promoting wound healing. In vivo studies further confirmed the biocompatibility and superior wound healing capabilities of SeTe–ZnO NP, highlighting their potential as a versatile and effective treatment for bacterial infections and wound care.