Recent progress in ZIF–polymer composites for advanced drug delivery applications

Abstract

This review article provides an in-depth study of recent advancements in ZIF–polymer composites, focusing on their transformative potential in drug delivery systems. It also reveals their multiple advantages, including increased drug loading efficiency, controlled and sustained release, and targeted delivery capabilities. In addition, this article explores various applications of ZIFs in diverse therapeutic areas such as orthopedic, ocular, transdermal, gastrointestinal, and pulmonary drug delivery. This review also offers key insights into the synthesis approaches, current scenario, and future directions of ZIF–polymer composites, along with some aspects of critical factors such as stimuli-responsiveness, stability, and toxicity. Zeolitic imidazolate frameworks (ZIFs), a new subclass of MOFs, are synthesized from tetrahedral metal ions and imidazolate linkers. ZIFs are valued for their exceptional porosity, robust chemical stability, and thermal characteristics. They show excellent compatibility with polymers and fabrication of ZIF–polymer hybrids with high loading efficiency is achieved using methods such as in situ synthesis, self-assembly, grafting, electrospinning, and microfluidic synthesis techniques. By consolidating knowledge of the role of ZIF–polymer hybrids in drug delivery, this article provides a valued resource for researchers and scientists seeking to revolutionize patient care through cutting-edge materials. It also emphasizes the potential of ZIF–polymer composites to redefine drug delivery systems and improve clinical outcomes, marking a significant milestone in the quest for ideal drug delivery platforms. In summary, this review emphasizes the importance of innovative ZIF-polymer materials as promising alternatives to conventional therapeutic systems, contributing to the development of advanced healthcare solutions.