Nanozyme mediated high entropy-driven photothermal enhanced tumor catalytic therapy

Abstract

Nanozymes mediated catalytic therapy has emerged as a promising strategy for antitumor treatment but it remains imperative to further improve the catalytic efficiency of nanozymes for a potentiated antitumor efficacy. Single-phase high entropy (HE) nanozymes with deisrable enzyme-like catalytic activity and photothermal property are appealing for potentiating the efficacy of catalytic therapy but have remained synthetically challenging. As a proof-of-concept demonstration, we herein prepared a single-phase HE Prussian blue analogue (HEPBA) by a conventional coprecipation method. The HE mixing state enabled an exceptional high photothermal conversion efficiency of 95.3 % and a notable photothermal enhanced peroxidase-like catalytic activity. As a result, the HEPBA mediated photothermal enhanced catalytic therapy led to a potentiated antitumor efficacy on both 4T1 and CT26 tumor-bearing mouse models. This work thereby provides a rational and flexible platform for convenient and green preparation of biocompatible HE nanozymes and offers new perspectives on HE nanozymes in potentiating the efficacy of catalytic therapy.