Facile preparation of phospholipid–amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration

Abstract

A facile solvent diffusion method was developed to prepare phospholipid–amorphous calcium carbonate (ACC) hybrid nanoparticles via a one-pot approach. The hybrid nanoparticles can specifically realize water-responsive burst drug release in cancer cells and potentiate drug penetration into deep tumor tissues for advanced cancer therapy.