Issue 1, 2001
From the journal:

Chemical Communications

Synthesis of a hybrid fullerene–trimethoxyindole–oligonucleotide conjugate

Massimo Bergamin,a   Tatiana Da Ros,a   Giampiero Spalluto,a   Alexandre Boutorineb  and  Maurizio Prato*a  

* Corresponding authors

a Dipartimento di Scienze Farmaceutiche, Università di Trieste, Piazzale Europa 1, Trieste, Italy
E-mail: prato@univ.trieste.it

b Laboratoire de Biophysique, INSERM U 201 - CNRS UMR 8646, Museum National d’Histoire Naturelle, 43 rue Cuvier, Paris, Cedex 05, France

Abstract

The synthesis of novel functionalized fullerene derivatives is reported: a DNA minor groove binder such as trimethoxy- indole-2-carboxylate (TMI) and an oligonucleotide chain have been covalently linked to C60 with the aim of duplicating DNA interactions for increasing sequence selectivity.

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Article information

DOI
https://doi.org/10.1039/B008744K
Article type
Communication
Submitted
30 Oct 2000
Accepted
14 Nov 2000
First published
11 Dec 2000

Chem. Commun., 2001, 17-18

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Synthesis of a hybrid fullerene–trimethoxyindole–oligonucleotide conjugate

M. Bergamin, T. Da Ros, G. Spalluto, A. Boutorine and M. Prato, Chem. Commun., 2001, 17 DOI: 10.1039/B008744K

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