Issue 3, 2005

Photothermal sensitisation: evidence for the lack of oxygen effect on the photosensitising activity

Abstract

Irradiation of amelanotic melanoma B78H1 cells in the presence of liposome-delivered Ni(II)-octabutoxy-naphthalocyanine with a Q-switched Ti:sapphire laser operated in a pulsed mode (850 nm, 30 ns pulses, 10 Hz, 120 mJ pulse−1) promotes a photothermal sensitization process leading to extensive cell inactivation. The photoprocess occurs with identical efficiency in N2-saturated and air-equilibrated media, indicating that this photosensitization modality does not require the presence of oxygen.

Graphical abstract: Photothermal sensitisation: evidence for the lack of oxygen effect on the photosensitising activity

Article information

Article type
Communication
Submitted
27 Oct 2004
Accepted
01 Feb 2005
First published
14 Feb 2005

Photochem. Photobiol. Sci., 2005,4, 251-253

Photothermal sensitisation: evidence for the lack of oxygen effect on the photosensitising activity

M. Camerin, M. A. J. Rodgers, M. E. Kenney and G. Jori, Photochem. Photobiol. Sci., 2005, 4, 251 DOI: 10.1039/B416418K

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