Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy

Chenxuan Wang; Xiaobo Mao; Aihua Yang; Lin Niu; Shengnan Wang; Denghua Li; Yuanyuan Guo; Yibing Wang; Yanlian Yang; Chen Wang

doi:10.1039/C1CC12380G

Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy†‡

Chenxuan Wang,§^ab Xiaobo Mao,§^a Aihua Yang,^a Lin Niu,^a Shengnan Wang,^a Denghua Li,^a Yuanyuan Guo,^a Yibing Wang,^a Yanlian Yang*^a and Chen Wang*^a

Author affiliations

* Corresponding authors

^a National Center for Nanoscience and Technology, Beijing 100190, China
E-mail: yangyl@nanoctr.cn, wangch@nanoctr.cn
Fax: +86-10-62656765
Tel: +86-10-82545561

^b Department of Chemistry, Tsinghua University, Beijing 100084, China

Abstract

The binding behaviour of labeling molecule copper phthalocyanine tetrasulfonate sodium (PcCu(SO₃Na)₄) on the assemblies of representative polyamino acids has been studied by using scanning tunneling microscopy (STM). By directly visualizing the adsorption and distribution of the labeling species on the peptide assemblies in STM images, one could obtain relative binding affinities of the labeling molecule with different amino acid residues.

This article is part of the themed collection: Molecule-based surface chemistry

Chemical Communications

Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy†‡

Abstract

Supplementary files

Article information

Download Citation

Permissions

Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy

Social activity

Search articles by author

Spotlight

Advertisements