Issue 30, 2011
From the journal:

Chemical Communications

Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives†‡

Li Ding,ab   Hai Yu,b   Kam Lau,b   Yanhong Li,b   Saddam Muthana,§b   Junru Wanga  and  Xi Chen*b  

* Corresponding authors

a College of Science, Northwest A&F University, Yangling, Shaanxi, China

b Department of Chemistry, University of California, One Shields Avenue, Davis, USA
E-mail: chen@chem.ucdavis.edu.edu
Fax: +1 530-752-8995
Tel: +1 530-754-6037

Abstract

An N-terminal and C-terminal truncated recombinant α2–6-sialyltransferase cloned from Photobacterium sp. JH-ISH-224, Psp2,6ST(15–501)-His6, was shown to be an efficient catalyst for one-pot three-enzyme synthesis of sialyl Tn (STn) antigens and derivatives containing natural and non-natural sialic acid forms.

Graphical abstract: Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives

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Article information

DOI
https://doi.org/10.1039/C1CC12732B
Article type
Communication
Submitted
10 May 2011
Accepted
15 Jun 2011
First published
01 Jul 2011

Chem. Commun., 2011,47, 8691-8693

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Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives

L. Ding, H. Yu, K. Lau, Y. Li, S. Muthana, J. Wang and X. Chen, Chem. Commun., 2011, 47, 8691 DOI: 10.1039/C1CC12732B

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