Issue 1, 2011
From the journal:

Organic & Biomolecular Chemistry

First total synthesis of (−)- and (+)-6-O-desmethylantofine†

Meng Wu,a   Ling Li,a   Bo Su,a   Zhihui Liua  and  Qingmin Wang*a  

* Corresponding authors

a State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, People's Republic of China
E-mail: wang98h@263.net
Fax: +86-22-23499842

Abstract

The first total synthesis of (−)-6-O-desmethylantofine (A) and its unnatural enantiomer (+)-6-O-desmethylantofine (B) is described. The synthetic route is efficient and practical with easily available glutamic acid dimethyl ester hydrochloride as the chiral material under mild conditions.

Graphical abstract: First total synthesis of (−)- and (+)-6-O-desmethylantofine

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Article information

DOI
https://doi.org/10.1039/C0OB00287A
Article type
Paper
Submitted
18 Jun 2010
Accepted
12 Aug 2010
First published
04 Nov 2010

Org. Biomol. Chem., 2011,9, 141-145

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First total synthesis of (−)- and (+)-6-O-desmethylantofine

M. Wu, L. Li, B. Su, Z. Liu and Q. Wang, Org. Biomol. Chem., 2011, 9, 141 DOI: 10.1039/C0OB00287A

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