Ruthenium-catalyzed intramolecular carbocyclization of alkynes with an sp3carbon involving an oxidative deprotonation process

Abstract

A novel RuCl₃-catalyzed intramolecular oxidative hydration–deprotonation–cyclization method was developed for the synthesis of substituted quinolinones. The method serves as the first example of direct carbocyclization of an alkyne with an sp³carbon at the α-position of an amide through an oxidative deprotonation process.