Issue 19, 2012
From the journal:

Chemical Communications

An artificial photosensitizer drug network for mitochondria-selective photodynamic therapy†

So Young Park,‡a   Kyung Taek Oh,‡b   Young Taik Oh,c   Nam Muk Oh,a   Yu Seok Yound  and  Eun Seong Lee*a  

* Corresponding authors

a Division of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon, Gyeonggi-do 420-743, Republic of Korea
E-mail: eslee@catholic.ac.kr

b College of Pharmacy, Chung-Ang University, 221 Heukseok dong, Dongjak-gu, Seoul 155-756, Republic of Korea

c Department of Diagnostic Radiology, Yonsei University College of Medicine, Shinchon-dong 134, Seoul, Republic of Korea

d School of Pharmacy, Sungkyunkwan University, 300 Cheoncheon-dong, Jangan-gu, Suwon 440-746, Republic of Korea

Abstract

We report a new class of photosensitizer drug networks that can home into mitochondria and provide geospatial phototoxicity for tumors. We take advantage of the cleavable chemical network between the photosensitizer drug and poly(ethylene glycol), and find a significant increase in the efficiency of the multimeric drug network in mitochondria uptake and tumor inhibition.

Graphical abstract: An artificial photosensitizer drug network for mitochondria-selective photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C2CC16087K
Article type
Communication
Submitted
30 Sep 2011
Accepted
10 Jan 2012
First published
27 Jan 2012

Chem. Commun., 2012,48, 2522-2524

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An artificial photosensitizer drug network for mitochondria-selective photodynamic therapy

S. Y. Park, K. T. Oh, Y. T. Oh, N. M. Oh, Y. S. Youn and E. S. Lee, Chem. Commun., 2012, 48, 2522 DOI: 10.1039/C2CC16087K

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