Issue 13, 2012
From the journal:

Chemical Communications

Organocatalytic asymmetric synthesis of 3-difluoroalkyl 3-hydroxyoxindoles†‡

Yun-Lin Liua  and  Jian Zhou*ab  

* Corresponding authors

a Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663N, Zhongshan Road, Shanghai 200062, P. R. China
E-mail: jzhou@chem.ecnu.edu.cn
Fax: +86-21-6223-4560

b State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, P. R. China

Abstract

We report the first example of highly enantioselective organocatalytic synthesis of 3-difluoroalkyl substituted 3-hydroxyoxindoles. The total synthesis of the difluoro analogue of convolutamydine E was achieved by this method.

Graphical abstract: Organocatalytic asymmetric synthesis of 3-difluoroalkyl 3-hydroxyoxindoles

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Article information

DOI
https://doi.org/10.1039/C2CC17140F
Article type
Communication
Submitted
17 Nov 2011
Accepted
16 Dec 2011
First published
20 Dec 2011

Chem. Commun., 2012,48, 1919-1921

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Organocatalytic asymmetric synthesis of 3-difluoroalkyl 3-hydroxyoxindoles

Y. Liu and J. Zhou, Chem. Commun., 2012, 48, 1919 DOI: 10.1039/C2CC17140F

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