Issue 22, 2012
From the journal:

Chemical Communications

Occurrence of spontaneous resolution of ketoprofen with a racemic crystal structure by simple crystallization under nonequilibrium preferential enrichment conditions†‡

Rajesh G. Gonnade,a   Sekai Iwama,a   Ryusuke Sugiwake,a   Kochunnoonny Manoj,a   Hiroki Takahashi,a   Hirohito Tsuea  and  Rui Tamura*a  

* Corresponding authors

a Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan
E-mail: tamura.rui.8c@kyoto-u.ac.jp
Fax: +81-75-753-7915
Tel: +81-75-753-6815

Abstract

Nearly racemic ketoprofen, which satisfies the requirements for the occurrence of preferential enrichment, was spontaneously resolved into the two enantiomers by simple crystallization under nonequilibrium conditions using high concentrations.

Graphical abstract: Occurrence of spontaneous resolution of ketoprofen with a racemic crystal structure by simple crystallization under nonequilibrium preferential enrichment conditions

  • This article is part of the themed collection: Chirality
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DOI
https://doi.org/10.1039/C2CC18132K
Article type
Communication
Submitted
29 Dec 2011
Accepted
26 Jan 2012
First published
27 Jan 2012

Chem. Commun., 2012,48, 2791-2793

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Occurrence of spontaneous resolution of ketoprofen with a racemic crystal structure by simple crystallization under nonequilibrium preferential enrichment conditions

R. G. Gonnade, S. Iwama, R. Sugiwake, K. Manoj, H. Takahashi, H. Tsue and R. Tamura, Chem. Commun., 2012, 48, 2791 DOI: 10.1039/C2CC18132K

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