Issue 44, 2012
From the journal:

Chemical Communications

Enantioselective Friedel–Crafts reactions between phenols and N-tosylaldimines catalyzed by a leucine-derived bifunctional catalyst†

Guo-Xing Lia  and  Jin Qu*a  

* Corresponding authors

a State key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
E-mail: qujin@nankai.edu.cn

Abstract

Enantioselective Friedel–Crafts reactions between phenols and N-tosylaldimines were developed using a bifunctional catalyst readily prepared from L-leucine. The chiral benzylic amine products were obtained in high yields (up to 96% yield) and good to high enantiomeric excesses (up to 95% ee).

Graphical abstract: Enantioselective Friedel–Crafts reactions between phenols and N-tosylaldimines catalyzed by a leucine-derived bifunctional catalyst

  • This article is part of the themed collection: Chirality
About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC31735D
Article type
Communication
Submitted
08 Mar 2012
Accepted
14 Apr 2012
First published
17 Apr 2012

Chem. Commun., 2012,48, 5518-5520

Permissions

Request permissions

Enantioselective Friedel–Crafts reactions between phenols and N-tosylaldimines catalyzed by a leucine-derived bifunctional catalyst

G. Li and J. Qu, Chem. Commun., 2012, 48, 5518 DOI: 10.1039/C2CC31735D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements