Issue 64, 2012

Catalytic asymmetric Mannich-type reactions of α-cyano α-sulfonyl carbanions

Abstract

An efficient asymmetric Mannich-type reaction of α-cyano α-sulfonyl carbanions has been achieved by exploiting the structural modularity and anion-recognition ability of chiral 1,2,3-triazolium ions. This protocol has proven to be applicable to a variety of N-Boc imines and cyanosulfones, affording β-amino α-cyanosulfones in excellent yields with high stereoselectivities.

Graphical abstract: Catalytic asymmetric Mannich-type reactions of α-cyano α-sulfonyl carbanions

Supplementary files

Article information

Article type
Communication
Submitted
03 Apr 2012
Accepted
16 May 2012
First published
16 May 2012

Chem. Commun., 2012,48, 7913-7915

Catalytic asymmetric Mannich-type reactions of α-cyano α-sulfonyl carbanions

K. Ohmatsu, A. Goto and T. Ooi, Chem. Commun., 2012, 48, 7913 DOI: 10.1039/C2CC32398B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements