Issue 77, 2012
From the journal:

Chemical Communications

Triplex-directed covalent cross-linking of a DNA nanostructure†‡

David A. Rusling,*a   Iris S. Nandhakumar,b   Tom Brownb  and  Keith R. Fox*a  

* Corresponding authors

a Centre for Biological Sciences, University of Southampton, Highfield, Southampton, UK
E-mail: K.R.Fox@soton.ac.uk, D.A.Rusling@soton.ac.uk
Fax: +44 (0)23 8059 5159
Tel: +44 (0)23 8059 4374

b School of Chemistry, University of Southampton, Southampton, UK

Abstract

The triplex approach to DNA recognition is exploited to direct covalent inter-strand cross-links to unique locations within a pre-assembled DNA nanostructure. This approach can be used to improve the stability of DNA nanostructures and demonstrates the feasibility of directing other reactive groups to unique locations within these complexes.

Graphical abstract: Triplex-directed covalent cross-linking of a DNA nanostructure

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Article information

DOI
https://doi.org/10.1039/C2CC35407A
Article type
Communication
Submitted
26 Jul 2012
Accepted
09 Aug 2012
First published
10 Aug 2012

Chem. Commun., 2012,48, 9592-9594

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Triplex-directed covalent cross-linking of a DNA nanostructure

D. A. Rusling, I. S. Nandhakumar, T. Brown and K. R. Fox, Chem. Commun., 2012, 48, 9592 DOI: 10.1039/C2CC35407A

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