Issue 99, 2012
From the journal:

Chemical Communications

One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines†‡

Vjekoslav Štrukil,*a   Boris Bartolec,a   Tomislav Portada,a   Ivica Đilović,b   Ivan Halaszc  and  Davor Margetić*a  

* Corresponding authors

a Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, HR-10002 Zagreb, Croatia
E-mail: vstrukil@irb.hr, margetid@irb.hr

b Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102A Zagreb, Croatia

c Division of Chemistry of Materials, Ruđer Bošković Institute, Bijenička cesta 54, HR-10002 Zagreb, Croatia

Abstract

Environmentally friendly one-pot synthesis of amides, bis-amides and dipeptides by mechanochemical carbodiimide-mediated coupling of carboxylic acids and amines is described; high reaction yields and simple aqueous work-up allow for the clean, practical and fast preparation of a variety of compounds containing the amide bond from readily accessible reagents.

Graphical abstract: One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines

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Article information

DOI
https://doi.org/10.1039/C2CC36613D
Article type
Communication
Submitted
11 Sep 2012
Accepted
29 Oct 2012
First published
30 Oct 2012

Chem. Commun., 2012,48, 12100-12102

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One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines

V. Štrukil, B. Bartolec, T. Portada, I. Đilović, I. Halasz and D. Margetić, Chem. Commun., 2012, 48, 12100 DOI: 10.1039/C2CC36613D

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