Issue 43, 2012

Synthesis and hybridization properties of oligonucleotides modified with 5-(1-aryl-1,2,3-triazol-4-yl)-2′-deoxyuridines

Abstract

Oligonucleotides modified with consecutive incorporations of 5-(1-aryl-1,2,3-triazol-4-yl)-2′-deoxyuridine monomers X–Z display strong thermal affinity and binding specificity toward RNA targets, due to formation of chromophore arrays in the major groove.

Graphical abstract: Synthesis and hybridization properties of oligonucleotides modified with 5-(1-aryl-1,2,3-triazol-4-yl)-2′-deoxyuridines

Supplementary files

Article information

Article type
Communication
Submitted
30 Aug 2012
Accepted
24 Sep 2012
First published
01 Oct 2012

Org. Biomol. Chem., 2012,10, 8575-8578

Synthesis and hybridization properties of oligonucleotides modified with 5-(1-aryl-1,2,3-triazol-4-yl)-2′-deoxyuridines

M. Kaura, P. Kumar and P. J. Hrdlicka, Org. Biomol. Chem., 2012, 10, 8575 DOI: 10.1039/C2OB26717A

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