Issue 44, 2012

Construction of ratiometric fluorescent sensors by ribonucleopeptides

Abstract

Ratiometric fluorescent sensors were constructed from RNA aptamers by generating modular ribonucleopeptide complexes. Fluorescent ribonucleopeptides containing fluorophore seminaphthorhodafluor tethered to their peptide subunit revealed a dual emission property, which permitted a ratiometric fluorescent measurement of a substrate-binding event. The strategy successfully afforded ratiometric fluorescent sensors for biologically active small ligands, tetracycline, dopamine and streptomycin.

Graphical abstract: Construction of ratiometric fluorescent sensors by ribonucleopeptides

Supplementary files

Article information

Article type
Communication
Submitted
31 Aug 2012
Accepted
04 Oct 2012
First published
04 Oct 2012

Org. Biomol. Chem., 2012,10, 8767-8769

Construction of ratiometric fluorescent sensors by ribonucleopeptides

C. Annoni, E. Nakata, T. Tamura, F. F. Liew, S. Nakano, M. L. Gelmi and T. Morii, Org. Biomol. Chem., 2012, 10, 8767 DOI: 10.1039/C2OB26722E

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