Issue 22, 2012
From the journal:

RSC Advances

A catalyst-free C–H hydroarylation of coumarin derived ortho-quinone methide (o-QM) with electron rich arenes in glycerol†

Atul Kumar,*a   Mukesh Kumar,a   Maneesh Kumar Guptaa  and  Lalit Prakash Guptaa  

* Corresponding authors

a Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, CSIR, Lucknow India
E-mail: dratulsax@gmail.com
Fax: 91-522-26234051
Tel: 91-522-2612411

Abstract

An efficient, catalyst-free approach for C–H hydroarylation of in situ generated ortho-quinone methide (o-QM) with electron rich arenes (tertiary aryl amines) in glycerol has been developed. Several C-3-benzylated 4-hydroxycoumarin and 4-hydroxypyrone have been synthesized in good to excellent yields under mild conditions.

Graphical abstract: A catalyst-free C–H hydroarylation of coumarin derived ortho-quinone methide (o-QM) with electron rich arenes in glycerol

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Article information

DOI
https://doi.org/10.1039/C2RA21056H
Article type
Communication
Submitted
28 May 2012
Accepted
30 Jul 2012
First published
31 Jul 2012

RSC Adv., 2012,2, 8277-8280

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A catalyst-free C–H hydroarylation of coumarin derived ortho-quinone methide (o-QM) with electron rich arenes in glycerol

A. Kumar, M. Kumar, M. K. Gupta and L. P. Gupta, RSC Adv., 2012, 2, 8277 DOI: 10.1039/C2RA21056H

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