O      2  -Protected diazeniumdiolate-modified silica nanoparticles for extended nitric oxide release from dental composites

Alexis W. Carpenter; Katelyn P. Reighard; Joseph E. Saavedra; Mark H. Schoenfisch

doi:10.1039/C3BM00153A

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O²-Protected diazeniumdiolate-modified silica nanoparticles for extended nitric oxide release from dental composites†

Alexis W. Carpenter,^a Katelyn P. Reighard,^a Joseph E. Saavedra^b and Mark H. Schoenfisch*^a

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* Corresponding authors

^a Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
E-mail: schoenfisch@unc.edu

^b Basic Science Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland, USA

Abstract

O ² -Protected N-diazeniumdiolate-based silanes were grafted onto mesoporous silica nanoparticles to yield a scaffold with an NO payload of 2.4 μmol NO per mg and NO release half-life of 23 d. Adhesion of Streptococcus mutans to dental restorative materials doped with these NO-releasing particles was reduced by 3-log compared to controls.

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Article information

DOI: https://doi.org/10.1039/C3BM00153A
Article type: Communication
Submitted: 18 Oct 2012
Accepted: 10 Jan 2013
First published: 24 Jan 2013

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Biomater. Sci., 2013,1, 456-459

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O ² -Protected diazeniumdiolate-modified silica nanoparticles for extended nitric oxide release from dental composites

A. W. Carpenter, K. P. Reighard, J. E. Saavedra and M. H. Schoenfisch, Biomater. Sci., 2013, 1, 456 DOI: 10.1039/C3BM00153A

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