Issue 39, 2013
From the journal:

Chemical Communications

A gold(iii) porphyrin complex as an anti-cancer candidate to inhibit growth of cancer-stem cells†‡

Ching Tung Lum,a   Alice Sze-Tsai Wong,b   Marie CM Lin,c   Chi-Ming Che*a  and  Raymond Wai-Yin Sun*a  

* Corresponding authors

a Department of Chemistry, State Key Laboratory of Synthetic Chemistry, and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong
E-mail: rwysun@hku.hk; cmche@hku.hk
Fax: +852-28592154

b School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong

c Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong

Abstract

A cytotoxic gold(III) complex of meso-tetraphenylporphyrin ([Au(TPP)]Cl, denoted gold-1a) blocks the self-renewal ability of cancer stem-like cells and shows appealing safety pharmacological profiles in rodents.

Graphical abstract: A gold(iii) porphyrin complex as an anti-cancer candidate to inhibit growth of cancer-stem cells

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Article information

DOI
https://doi.org/10.1039/C2CC37366A
Article type
Communication
Submitted
09 Oct 2012
Accepted
15 Nov 2012
First published
16 Nov 2012

Chem. Commun., 2013,49, 4364-4366

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A gold(III) porphyrin complex as an anti-cancer candidate to inhibit growth of cancer-stem cells

C. T. Lum, A. S. Wong, M. C. Lin, C. Che and R. W. Sun, Chem. Commun., 2013, 49, 4364 DOI: 10.1039/C2CC37366A

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