Issue 12, 2013
From the journal:

Chemical Communications

DNA nanostructure serum stability: greater than the sum of its parts†‡

Justin W. Conway,a   Christopher K. McLaughlin,a   Katherine J. Castora  and  Hanadi Sleiman*a  

* Corresponding authors

a Department of Chemistry, 801 Sherbrooke St. West, Montreal, QC, Canada
E-mail: hanadi.sleiman@mcgill.ca
Tel: +1 514-398-2633

Abstract

Simple chemical modifications to oligonucleotide ends with hexaethylene glycol and hexanediol are shown to significantly increase nuclease resistance under serum conditions. The modified oligonucleotides were used to construct DNA prismatic cages in a single step and in quantitative yield. These cages further stabilize their strands towards nucleases, with lifetimes of 62 hours in serum. The cages contain a large number of single-stranded regions for functionalization, illustrating their versatility for biological applications.

Graphical abstract: DNA nanostructure serum stability: greater than the sum of its parts

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC37556G
Article type
Communication
Submitted
17 Oct 2012
Accepted
12 Dec 2012
First published
19 Dec 2012

Chem. Commun., 2013,49, 1172-1174

Permissions

Request permissions

DNA nanostructure serum stability: greater than the sum of its parts

J. W. Conway, C. K. McLaughlin, K. J. Castor and H. Sleiman, Chem. Commun., 2013, 49, 1172 DOI: 10.1039/C2CC37556G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements