Issue 1, 2013
From the journal:

Organic & Biomolecular Chemistry

Pd-catalyzed coupling reaction of fluorinated propargyl amidines with aryl iodides†

Shan Li,a   Yafen Yuan,a   Yajun Li,ab   Zhengke Li,a   Lisi Zhanga  and  Yongming Wu*a  

* Corresponding authors

a Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
E-mail: ymwu@sioc.ac.cn
Fax: (+86)-021-54925190

b School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, Hubei 430074, China

Abstract

Catalyzed by ligand free Pd(OAc)2, 2,5-disubstituted imidazole was prepared in good yield by the reaction of fluorinated propargyl amidines with iodoarene. Mechanistic studies indicated that this transformation occurs through a nitropalladation–reductive elimination pathway.

Graphical abstract: Pd-catalyzed coupling reaction of fluorinated propargyl amidines with aryl iodides

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Article information

DOI
https://doi.org/10.1039/C2OB26377G
Article type
Communication
Submitted
17 Jul 2012
Accepted
16 Oct 2012
First published
16 Oct 2012

Org. Biomol. Chem., 2013,11, 41-43

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Pd-catalyzed coupling reaction of fluorinated propargyl amidines with aryl iodides

S. Li, Y. Yuan, Y. Li, Z. Li, L. Zhang and Y. Wu, Org. Biomol. Chem., 2013, 11, 41 DOI: 10.1039/C2OB26377G

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