Synthesis and characterization of hydroxyapatite on hydrolyzed polyacrylonitrile nanofiber templates

Abstract

In mimicking the chemical structure of collagen nanofiber, electrospun polyacrylonitrile nanofibers were hydrolyzed to generate amide and carboxyl groups on the fiber surface. These fibers were applied as templates in bio-mimicking the growth of hydroxyapaptite (HAp). Nucleation and growth of HAp crystals were fast, and bioactive HAp/fiber composites were produced. The composite scaffold was non-cytotoxic to human dental pulp stem cells.