Issue 28, 2013
From the journal:

RSC Advances

A genetically active nano-calcium phosphate paste for bone substitution, encoding the formation of BMP-7 and VEGF-A

Svitlana Chernousova,a   Jan Klesing,a   Nadiia Soklakovaa  and  Matthias Epple*a  

* Corresponding authors

a Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr 5–7, 45117 Essen, Germany
E-mail: matthias.epple@uni-due.de

Abstract

Calcium phosphate nanoparticles with different compositions and morphologies loaded with DNA were prepared. Plasmids which encoded either bone morphogenetic protein 7 (BMP-7) or vascular endothelial growth factor A (VEGF-A) were used for transfection in epithelial cells (HeLa), osteoblast-like cells (MG-63), and human mesenchymal stem cells (hMSC). In particular, cationic nanoparticles showed high transfection efficiency together with low cytotoxicity. The nanoparticles can either be used in dispersion or added to a calcium phosphate paste for injection into bone defects.

Graphical abstract: A genetically active nano-calcium phosphate paste for bone substitution, encoding the formation of BMP-7 and VEGF-A

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Article information

DOI
https://doi.org/10.1039/C3RA23450A
Article type
Paper
Submitted
22 Dec 2012
Accepted
30 Jan 2013
First published
31 Jan 2013

RSC Adv., 2013,3, 11155-11161

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A genetically active nano-calcium phosphate paste for bone substitution, encoding the formation of BMP-7 and VEGF-A

S. Chernousova, J. Klesing, N. Soklakova and M. Epple, RSC Adv., 2013, 3, 11155 DOI: 10.1039/C3RA23450A

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