Issue 1, 2014
From the journal:

Analyst

Target-induced quenching for highly sensitive detection of nucleic acids based on label-free luminescent supersandwich DNA/silver nanoclusters†

Guangfeng Wang,*a   Yanhong Zhu,a   Ling Chen,a   Lun Wanga  and  Xiaojun Zhang*a  

* Corresponding authors

a Key Laboratory of Chem-Biosensing, College of Chemistry and Materials Science, Center for Nano Science and Technology, Anhui Normal University, Wuhu 241000, Anhui Province, P.R. China
E-mail: xjzhang@mail.ahnu.edu.cn
Fax: +86-553-3869303
Tel: +86-553-3869303

Abstract

Luminescent silver nanoclusters (AgNCs) were anchored by designed oligonucleotides, acting as fluorescent labels. They hybridized with specific nucleic acid targets to form a supersandwich structure resulting in the fluorescence intensity of the DNA/AgNCs decreasing linearly with respect to the concentration of the target DNA.

Graphical abstract: Target-induced quenching for highly sensitive detection of nucleic acids based on label-free luminescent supersandwich DNA/silver nanoclusters

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Article information

DOI
https://doi.org/10.1039/C3AN01702H
Article type
Paper
Submitted
08 Sep 2013
Accepted
08 Oct 2013
First published
08 Oct 2013

Analyst, 2014,139, 165-169

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Target-induced quenching for highly sensitive detection of nucleic acids based on label-free luminescent supersandwich DNA/silver nanoclusters

G. Wang, Y. Zhu, L. Chen, L. Wang and X. Zhang, Analyst, 2014, 139, 165 DOI: 10.1039/C3AN01702H

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