Issue 35, 2014

Constitutional self-selection from dynamic combinatorial libraries in aqueous solution through supramolecular interactions

Abstract

We describe the predominant formation of a specific constitution arising from the combination of building blocks with different topologies through disulphide chemistry in a Dynamic Combinatorial Library (DCL). The supramolecular interactions established by a zwitterionic cysteine moiety are responsible for the self-selection of one product from all the virtual members of a large library.

Graphical abstract: Constitutional self-selection from dynamic combinatorial libraries in aqueous solution through supramolecular interactions

Supplementary files

Article information

Article type
Communication
Submitted
11 Jan 2014
Accepted
27 Feb 2014
First published
05 Mar 2014

Chem. Commun., 2014,50, 4564-4566

Author version available

Constitutional self-selection from dynamic combinatorial libraries in aqueous solution through supramolecular interactions

J. Solà, M. Lafuente, J. Atcher and I. Alfonso, Chem. Commun., 2014, 50, 4564 DOI: 10.1039/C4CC00245H

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