The first enantioselective synthesis of β-aryl-substituted α-nitroepoxides, exploiting an organocatalyzed aminolytic kinetic resolution (AKR), has been developed. Ring-opening reaction of racemic α-nitroepoxides with aniline in the presence of a readily available Cinchona alkaloid-derived thiourea affords unreacted epoxides in up to 95% ee.
S. Meninno, L. Napolitano and A. Lattanzi, Catal. Sci. Technol., 2015, 5, 124 DOI: 10.1039/C4CY01157K
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