Issue 34, 2016
From the journal:

Chemical Communications

How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stability†

G. Kuminek,a   N. Rodríguez-Hornedo,*a   S. Siedler,b   H. V. A. Rocha,c   S. L. Cuffinibd  and  S. G. Cardosob  

* Corresponding authors

a Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA
E-mail: nrh@umich.edu

b Quality Control Laboratory, Post Graduate Program in Pharmacy, Universidade Federal de Santa Catarina, Florianópolis, Brazil

c Laboratory of Advanced Pharmaceutical Systems, Farmanguinhos, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil

d Institute of Science and Technology, Post Graduate Program in Materials Science and Engineering, Universidade Federal de São Paulo, São Paulo, SP, Brazil

Abstract

Cocrystals of a weakly basic drug (nevirapine) with acidic coformers are shown to alter the solubility dependence on pH, and to exhibit a pHmax above which a less soluble cocrystal becomes more soluble than the drug. The cocrystal solubility advantage can be dialed up or down by solution pH.

Graphical abstract: How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stability

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Article information

DOI
https://doi.org/10.1039/C6CC00898D
Article type
Communication
Submitted
28 Jan 2016
Accepted
29 Mar 2016
First published
29 Mar 2016

Chem. Commun., 2016,52, 5832-5835

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How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stability

G. Kuminek, N. Rodríguez-Hornedo, S. Siedler, H. V. A. Rocha, S. L. Cuffini and S. G. Cardoso, Chem. Commun., 2016, 52, 5832 DOI: 10.1039/C6CC00898D

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