An acid-cleavable phthalocyanine tetramer as an activatable photosensitiser for photodynamic therapy

Abstract

An acetal-linked self-quenched zinc(II) phthalocyanine tetramer has been prepared. In an acidic environment in phosphate buffered saline or inside tumour cells, the phthalocyanine units of the tetramer are separated thereby restoring the fluorescence emission and singlet oxygen production. This response enables this compound to serve as a promising activatable photosensitiser for photodynamic therapy.