Issue 45, 2018

The distinct structural preferences of tau protein repeat domains

Abstract

The tau fibrillar structures from the brain of an Alzheimer's patient have a core with a C-shaped motif of the third and fourth repeat domains (R3–R4). Our simulations indicated that the C-shaped motif is only stable for R3–R4, while R1–R2 tends to be linear in shape. These two structural motifs appear in the most stable K18 protofilament. Heparin can further stabilize the C-shaped R3–R4 motif, but not other repeats.

Graphical abstract: The distinct structural preferences of tau protein repeat domains

Supplementary files

Article information

Article type
Communication
Submitted
13 Feb 2018
Accepted
08 May 2018
First published
08 May 2018

Chem. Commun., 2018,54, 5700-5703

The distinct structural preferences of tau protein repeat domains

X. Li, X. Dong, G. Wei, M. Margittai, R. Nussinov and B. Ma, Chem. Commun., 2018, 54, 5700 DOI: 10.1039/C8CC01263F

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